Article date: April 1975
By: MH Greenwood, MH Lader, BD Kantameneni, G Curzon, in Volume 2, Issue 2, pages 165-172
1 The psychotropic effects of a single oral dose of (‐)‐tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self‐ratings of mood showed increase in drowsiness but no euphoria was detected. 3 Severe initial nausea occurred and headache increased; other bodily symptoms were unaffected. 4 Trptophan caused increased activity in the slow wavebands of the EEG but did not alter the other physiological measures. 5 The levels of total and free tryptophan in the plasma increased 8 and 20 fold respectively to peak levels 2 h after ingestion.
DOI: 10.1111/j.1365-2125.1975.tb01572.x
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