Article date: June 1981
By: DR Lima, S Kilfeather, A Hedges, P Turner, in Volume 11, Issue 6, pages 555-559
1 The influence of acebutolol, atenolol, pindolol and timolol on human lymphocyte cyclic AMP (cAMP) and its stimulation by isoprenaline in vitro has been studied. 2 Acebutolol and atenolol (10(‐8)‐10(‐6)M) had no significant influence on lymphocyte cAMP levels or on isoprenaline‐ stimulated increase in cAMP. 3 Pindolol and timolol significantly antagonised the effect of isoprenaline, and pA2 values were calculated to be 8.12 and 8.04 respectively. This suggests that beta 2‐ adrenoceptors are involved in this phenomenon. 4 Only pindolol produced a significant increase in lymphocyte cAMP, which is consistent with its partial agonist activity.
DOI: 10.1111/j.1365-2125.1981.tb01170.x
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