Article date: February 1989
By: Alexander Filippov, Evgeny Kobrinsky, Vladimir Porotikov, Maya Saxon in Volume 96, Issue 2, pages 253-255
A dihydropyridine CGP 28861 (5 × 10−6m) did not change slow inward Ca current as measured by the double sucrose gap method in frog atrial fibres but decreased the agonist effects of Bay K 8644, CGP 28392, (+m)−(S)−202–791 and the antagonist effects of nifedipine and (+m)−(PN)−200–110. Paradoxically, the weak antagonists (−)−(R)−202–791, (−)−(PN)−200–110 and (+)‐Bay K 8644 increased Ca‐current after washout of CGP 28861. These data suggest that CGP 28861 can convert the dihydropyridine Ca‐channel receptor from an antagonistic site into an agonistic one.
DOI: 10.1111/j.1476-5381.1989.tb11808.x
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