Article date: February 1989
By: W.R. Dunn, J.C. McGrath, V.G. Wilson in Volume 96, Issue 2, pages 259-261
In the rabbit isolated distal saphenous artery, the population of postjunctional adrenoceptors is of the α1 variety under normal in vitro experimental conditions, based on the potency order of selective agonists and on the effects of the antagonists prazosin and rauwolscine against responses to UK‐14304. Angiotensin II (AII, 0.05 μm) however, without affecting resting baseline tension, markedly enhanced responses to UK‐14304, particularly at low concentrations. This previously unseen component of the response to UK‐14304 was resistant to prazosin (0.1 μm) but susceptible to rauwolscine (1 μm). AII would therefore appear to have a permissive role for the expression of a quiescent population of postjunctional α2‐adrenoceptors in the rabbit distal saphenous artery.
DOI: 10.1111/j.1476-5381.1989.tb11810.x
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