Article date: November 1987
By: Wolfgang Osterrieder in Volume 92, Issue 3, pages 521-525
9‐Amino‐1,2,3,4‐tetrahydroacridine (THA) is a compound with structural similarity to the K+ channel blocker 4‐aminopyridine. It was investigated for its effects on myocardial membrane currents in guinea‐pig isolated ventricular myocytes.
THA prolonged the transmembrane action potential and decreased the amplitude of its plateau in a reversible manner.
Voltage‐clamp experiments showed that THA reduced the inwardly rectifying and the time‐dependent outward K+ currents as well as the slow inward Ca2+ current.
The degree of block of the inwardly rectifying K+ current depended on the membrane potential, being more pronounced at more positive potentials.
9‐Amino‐1,2,3,4‐tetrahydroacridine (THA) is a compound with structural similarity to the K+ channel blocker 4‐aminopyridine. It was investigated for its effects on myocardial membrane currents in guinea‐pig isolated ventricular myocytes.
THA prolonged the transmembrane action potential and decreased the amplitude of its plateau in a reversible manner.
Voltage‐clamp experiments showed that THA reduced the inwardly rectifying and the time‐dependent outward K+ currents as well as the slow inward Ca2+ current.
The degree of block of the inwardly rectifying K+ current depended on the membrane potential, being more pronounced at more positive potentials.
DOI: 10.1111/j.1476-5381.1987.tb11352.x
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