Article date: May 1985
By: Jacqueline Goodall, I.E. Hughes, D. Mackay in Volume 85, Issue 1, pages 277-283
The effects of the opioid receptor agonist RX783006 and of the opioid receptor partial agonist (+)‐meptazinol have been examined on electrically‐induced twitch responses of the guinea‐pig isolated ileum and of the mouse isolated vas deferens.
Log10 concentration‐tissue state curves were determined for (+)‐meptazinol and for RX783006, alone, in combination and, when appropriate, in the presence of naloxone (30 nM).
Analysis of these log10 concentration‐tissue state curves using the null equations derived and verified in the previous paper allows quantitation of the characteristics of the interaction of (+)‐meptazinol with the opioid receptors in these tissues.
The results indicate that the apparent differences in the actions of (+)‐meptazinol on isolated electrically‐stimulated guinea‐pig ileum and mouse vas deferens can be accounted for without the need to postulate differences between μ‐opioid receptors in these two tissues.
The effects of the opioid receptor agonist RX783006 and of the opioid receptor partial agonist (+)‐meptazinol have been examined on electrically‐induced twitch responses of the guinea‐pig isolated ileum and of the mouse isolated vas deferens.
Log10 concentration‐tissue state curves were determined for (+)‐meptazinol and for RX783006, alone, in combination and, when appropriate, in the presence of naloxone (30 nM).
Analysis of these log10 concentration‐tissue state curves using the null equations derived and verified in the previous paper allows quantitation of the characteristics of the interaction of (+)‐meptazinol with the opioid receptors in these tissues.
The results indicate that the apparent differences in the actions of (+)‐meptazinol on isolated electrically‐stimulated guinea‐pig ileum and mouse vas deferens can be accounted for without the need to postulate differences between μ‐opioid receptors in these two tissues.
DOI: 10.1111/j.1476-5381.1985.tb08857.x
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