Article date: May 1985
By: C. J. Lote, A.J. McVicar, A. Thewles in Volume 85, Issue 1, pages 7-10
Tiaprofenic acid (Surgam, Cassenne) was administered intravenously to saline‐diuretic conscious rats, at doses of 2, 10 and 25 mg kg−1 body weight.
Tiaprofenic acid significantly reduced urinary prostaglandin E2 (PGE2) and 6 keto PGF1α excretion, at all three doses employed. The extent of the reduction was similar for both PGE2 and 6 keto PGF1α output; hence no evidence of ‘selectivity’ (i.e. sparing of PGI2 synthesis) was observed.
Tiaprofenic acid was also administered to rats receiving an infusion of 5% dextrose. The dose employed (0.5 or 1 mg kg−1 body weight) was submaximal and elicited reductions in PGE2 output to values still more than 60% of the control period values. In this group of animals, the percentage change in 6 keto PGF1α excretion was again not significantly different from that of PGE2.
The maximal extent of reduction in urinary PGE2 excretion with tiaprofenic acid (25 mg kg−1 body weight) was not significantly different from that elicited by indomethacin (10 mg kg−1 body weight), although the time course of the reduction was different.
Tiaprofenic acid (Surgam, Cassenne) was administered intravenously to saline‐diuretic conscious rats, at doses of 2, 10 and 25 mg kg−1 body weight.
Tiaprofenic acid significantly reduced urinary prostaglandin E2 (PGE2) and 6 keto PGF1α excretion, at all three doses employed. The extent of the reduction was similar for both PGE2 and 6 keto PGF1α output; hence no evidence of ‘selectivity’ (i.e. sparing of PGI2 synthesis) was observed.
Tiaprofenic acid was also administered to rats receiving an infusion of 5% dextrose. The dose employed (0.5 or 1 mg kg−1 body weight) was submaximal and elicited reductions in PGE2 output to values still more than 60% of the control period values. In this group of animals, the percentage change in 6 keto PGF1α excretion was again not significantly different from that of PGE2.
The maximal extent of reduction in urinary PGE2 excretion with tiaprofenic acid (25 mg kg−1 body weight) was not significantly different from that elicited by indomethacin (10 mg kg−1 body weight), although the time course of the reduction was different.
DOI: 10.1111/j.1476-5381.1985.tb08824.x
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