Article date: February 1984
By: G. Autore, F. Capasso, N. Mascolo in Volume 81, Issue 2, pages 347-349
The effects of Phenolphthalein on the formation of histamine, 5‐hydroxytryptamine (5‐HT) and prostaglandin‐like material by rat intestine were examined in vivo.
Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5‐HT and prostaglandin‐like material, and indomethacin reduced these increases.
The data support the idea that the laxative effect of Phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5‐HT.
The effects of Phenolphthalein on the formation of histamine, 5‐hydroxytryptamine (5‐HT) and prostaglandin‐like material by rat intestine were examined in vivo.
Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5‐HT and prostaglandin‐like material, and indomethacin reduced these increases.
The data support the idea that the laxative effect of Phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5‐HT.
DOI: 10.1111/j.1476-5381.1984.tb10085.x
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