Article date: February 1984
By: R.E. Carraway, D.E. Cochrane, C. Granier, P. Kitabgi, Eve Leeman, E.A. Singer in Volume 81, Issue 2, pages 227-229
The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5‐hydroxytryptamine (5‐HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5‐HT and histamine. Amitriptyline prevented the secretion of histamine in response to stimulation by neurotensin, substance P, somatostatin or compound 48/80 but was without effect on the secretion of endogenous 5‐HT.
DOI: 10.1111/j.1476-5381.1984.tb10069.x
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