Article date: February 1984
By: Y. Abiko, T. Nishimura, K. Sakai in Volume 81, Issue 2, pages 409-411
In dogs anaesthetized with pentobarbitone, the left anterior descending coronary artery (LAD) was partially occluded. Before and 30 min after partial occlusion, the myocardial pH was 7.52–7.54 and 6.89–6.91, respectively.
Nicorandil (50 μg kg−1, i.v.) increased the pH that had been reduced by partial occlusion and this effect lasted at least 60 min. Thus nicorandil attenuates ischaemic myocardial acidosis.
In dogs anaesthetized with pentobarbitone, the left anterior descending coronary artery (LAD) was partially occluded. Before and 30 min after partial occlusion, the myocardial pH was 7.52–7.54 and 6.89–6.91, respectively.
Nicorandil (50 μg kg−1, i.v.) increased the pH that had been reduced by partial occlusion and this effect lasted at least 60 min. Thus nicorandil attenuates ischaemic myocardial acidosis.
DOI: 10.1111/j.1476-5381.1984.tb10093.x
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