Article date: November 1982
By: A.V. JUORIO in Volume 77, Issue 3, pages 511-515
The concentrations of p‐ and m‐tyramine, dopamine and homovanillic acid were measured in the mouse striatum following the subcutaneous administration of amfonelic acid, (+)‐amphetamine or nomifensine.
The administration of 2.5 −25 mg/kg of amfonelic acid produced a reduction in p‐tyramine that lasted at least 8 h. m‐Tyramine was significantly increased and this was observed between 2 and 24 h after drug treatment. The levels of homovanillic acid were increased within 4 h after amfonelic acid administration.
(+)‐Amphetamine treatment (5 mg/kg) produced a reduction in p‐tyramine observed up to 4 h after its administration and no significant changes in m‐tyramine.
The administration of 10 mg/kg of nomifensine produced no significant changes in p‐tyramine, m‐tyramine or homovanillic acid. By increasing the dose to 20 mg/kg, nomifensine produced an increase in p‐tyramine and homovanillic acid.
The present results support the view that amfonelic acid and (+)‐amphetamine would respectively release granular or newly synthesized dopamine, both actions being accompanied by an increase in tyrosine hydroxylase activity and dopamine turnover which in turn reduces p‐tyramine but produces no change or an increase in m‐tyramine.
The effects of nomifensine were observed after the administration of a relatively high dose (20 mg/kg), that was lethal to some mice (about 20%, at 2 h), and more likely to possess unspecific actions.
The concentrations of p‐ and m‐tyramine, dopamine and homovanillic acid were measured in the mouse striatum following the subcutaneous administration of amfonelic acid, (+)‐amphetamine or nomifensine.
The administration of 2.5 −25 mg/kg of amfonelic acid produced a reduction in p‐tyramine that lasted at least 8 h. m‐Tyramine was significantly increased and this was observed between 2 and 24 h after drug treatment. The levels of homovanillic acid were increased within 4 h after amfonelic acid administration.
(+)‐Amphetamine treatment (5 mg/kg) produced a reduction in p‐tyramine observed up to 4 h after its administration and no significant changes in m‐tyramine.
The administration of 10 mg/kg of nomifensine produced no significant changes in p‐tyramine, m‐tyramine or homovanillic acid. By increasing the dose to 20 mg/kg, nomifensine produced an increase in p‐tyramine and homovanillic acid.
The present results support the view that amfonelic acid and (+)‐amphetamine would respectively release granular or newly synthesized dopamine, both actions being accompanied by an increase in tyrosine hydroxylase activity and dopamine turnover which in turn reduces p‐tyramine but produces no change or an increase in m‐tyramine.
The effects of nomifensine were observed after the administration of a relatively high dose (20 mg/kg), that was lethal to some mice (about 20%, at 2 h), and more likely to possess unspecific actions.
DOI: 10.1111/j.1476-5381.1982.tb09325.x
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