Article date: November 1982
By: K.T. BUNCE, C.F. SPRAGGS in Volume 77, Issue 3, pages 469-475
The effect of chlorpromazine (Cpz) on the net fluxes of water and sodium in the ileum and colon has been studied in the anaesthetized rat.
Under control conditions both the ileum and colon absorbed water and sodium. Cpz (100 μmol/kg, s.c.) had no significant effect on these basal rates of absorption.
Intestinal secretion was stimulated by a combination of intra‐arterial prostaglandin E1 (PGE1; 10 nmol kg−1 min−1) and intraluminal theophylline (25 mm). A marked potentiation occurred between PGE1 and theophylline in the stimulation of colonic and ileal secretion.
In the ileum, a dose‐related inhibition of the PGE1/theophylline‐induced changes in the net fluxes of water and sodium was produced by Cpz (0.1 to 100 μmol/kg, s.c.). Under these conditions the inhibition of the secretagogue‐induced changes was significant using Cpz at 1 μmol/kg (s.c.) and a dose of Cpz of 100 μmol/kg (s.c.) returned the net fluxes of both water and sodium to basal levels.
In the colon, Cpz, at doses of 0.1 and 1 μmol/kg subcutaneously did not inhibit the PGE1/theophylline‐induced changes in the net fluxes of water and sodium, and, in contrast with the ileum, significant changes were only obtained with Cpz at 10 μmol/kg. Increasing the dose of Cpz to 100 μmol/kg further inhibited the net flux of sodium, but not that of water in the colon, and in each case the secretagogue‐induced changes were not returned to basal levels.
The effect of chlorpromazine (Cpz) on the net fluxes of water and sodium in the ileum and colon has been studied in the anaesthetized rat.
Under control conditions both the ileum and colon absorbed water and sodium. Cpz (100 μmol/kg, s.c.) had no significant effect on these basal rates of absorption.
Intestinal secretion was stimulated by a combination of intra‐arterial prostaglandin E1 (PGE1; 10 nmol kg−1 min−1) and intraluminal theophylline (25 mm). A marked potentiation occurred between PGE1 and theophylline in the stimulation of colonic and ileal secretion.
In the ileum, a dose‐related inhibition of the PGE1/theophylline‐induced changes in the net fluxes of water and sodium was produced by Cpz (0.1 to 100 μmol/kg, s.c.). Under these conditions the inhibition of the secretagogue‐induced changes was significant using Cpz at 1 μmol/kg (s.c.) and a dose of Cpz of 100 μmol/kg (s.c.) returned the net fluxes of both water and sodium to basal levels.
In the colon, Cpz, at doses of 0.1 and 1 μmol/kg subcutaneously did not inhibit the PGE1/theophylline‐induced changes in the net fluxes of water and sodium, and, in contrast with the ileum, significant changes were only obtained with Cpz at 10 μmol/kg. Increasing the dose of Cpz to 100 μmol/kg further inhibited the net flux of sodium, but not that of water in the colon, and in each case the secretagogue‐induced changes were not returned to basal levels.
DOI: 10.1111/j.1476-5381.1982.tb09320.x
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