Article date: August 1982
By: R.J. MARSHALL, A.W. MUIR, EILEEN WINSLOW in Volume 76, Issue 4, pages 501-503
The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation‐induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the incidence of ventricular fibrilloflutter and completely prevented electrical deaths (45% in the controls). Protection was also seen when the drugs were given just before the expected onset of arrhythmias (4.5 min postligation).
DOI: 10.1111/j.1476-5381.1982.tb09245.x
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