Article date: February 1980
By: A.A. ALMOTREFI, J.B.E. BAKER in Volume 71, Issue 2, pages 635-639
The electrical stimulation and ventricular fibrillation thresholds were measured in the Langendorff‐perfused rabbit heart by application of rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively.
Perfusion with either phenytoin or mexiletine produced significant dose‐dependent increases in both thresholds.
Perfusion with four anticonvulsant inhibitors of γ‐aminobutyric acid (GABA)‐transaminase, amino‐oxyacetic acid, γ‐acetylenic GABA, γ‐vinyl GABA and sodium valproate, up to a concentration of 20 μg/ml, had no significant effect on either threshold.
The results suggest that these compounds, unlike phenytoin and mexiletine, are devoid of antifibrillatory activity.
The electrical stimulation and ventricular fibrillation thresholds were measured in the Langendorff‐perfused rabbit heart by application of rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively.
Perfusion with either phenytoin or mexiletine produced significant dose‐dependent increases in both thresholds.
Perfusion with four anticonvulsant inhibitors of γ‐aminobutyric acid (GABA)‐transaminase, amino‐oxyacetic acid, γ‐acetylenic GABA, γ‐vinyl GABA and sodium valproate, up to a concentration of 20 μg/ml, had no significant effect on either threshold.
The results suggest that these compounds, unlike phenytoin and mexiletine, are devoid of antifibrillatory activity.
DOI: 10.1111/j.1476-5381.1980.tb10984.x
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