Article date: February 1980
By: LOUISE ENNS, E.E. McCOY in Volume 71, Issue 2, pages 553-556
Initial uptake rates of γ‐aminobutyric acid (GABA) were compared in Down's syndrome (D.S.) and normal platelets. GABA uptake was decreased in D.S. platelets (1.10 ± 0.10 nmol h−1 10−9) compared to uptake by normal platelets (1.89 ± 0.21 nmol h−1 10−9), P < 0.005.
The effect of varying the Na+ concentration was similar on D.S. and normal platelets. Increasing the media Na+ concentration resulted in increased rates of GABA uptake in both D.S. and normal platelets.
GABA uptake in the presence of 2,4‐dinitrophenol or at 2°C is approximately 56% of the uptake at 37°C for both D.S. and normal platelets.
Extrapolation of a reciprocal plot indicates a two affinity uptake system: a high affinity and a low affinity mechanism.
A significant defect in GABA uptake exists in D.S. platelets.
Initial uptake rates of γ‐aminobutyric acid (GABA) were compared in Down's syndrome (D.S.) and normal platelets. GABA uptake was decreased in D.S. platelets (1.10 ± 0.10 nmol h−1 10−9) compared to uptake by normal platelets (1.89 ± 0.21 nmol h−1 10−9), P < 0.005.
The effect of varying the Na+ concentration was similar on D.S. and normal platelets. Increasing the media Na+ concentration resulted in increased rates of GABA uptake in both D.S. and normal platelets.
GABA uptake in the presence of 2,4‐dinitrophenol or at 2°C is approximately 56% of the uptake at 37°C for both D.S. and normal platelets.
Extrapolation of a reciprocal plot indicates a two affinity uptake system: a high affinity and a low affinity mechanism.
A significant defect in GABA uptake exists in D.S. platelets.
DOI: 10.1111/j.1476-5381.1980.tb10972.x
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