Article date: April 1980
By: VICTORIA A. JAMES, R.J. WALKER, H.V. WHEAL in Volume 68, Issue 4, pages 711-717
Intracellular recordings were made from Retzius cells from the segmental ganglia of Hirudo medicinalis and Haemopis sanguisuga. Glutamate had a direct excitatory effect on the leech Retzius cells.
l‐Glutamate was 25 times more potent than d‐glutamate.
l‐Glutamate was approximately equipotent with ibotenic acid and 11.2 times more potent than l‐aspartic acid.
Quisqualic acid and kainic acid were both approximately 100 times more potent than l‐glutamate. dl‐1‐Amino‐cis‐1,3‐dicarboxycyclopentane was approximately 5 times more potent than l‐glutamate, while the trans isomer was 105 times less potent.
α‐NH2‐pimelic acid and β‐CH3‐glutamic acid reduced the response to l‐glutamate.
It is suggested that glutamic acid may interact with the Retzius cell glutamate receptor in an extended conformation.
Intracellular recordings were made from Retzius cells from the segmental ganglia of Hirudo medicinalis and Haemopis sanguisuga. Glutamate had a direct excitatory effect on the leech Retzius cells.
l‐Glutamate was 25 times more potent than d‐glutamate.
l‐Glutamate was approximately equipotent with ibotenic acid and 11.2 times more potent than l‐aspartic acid.
Quisqualic acid and kainic acid were both approximately 100 times more potent than l‐glutamate. dl‐1‐Amino‐cis‐1,3‐dicarboxycyclopentane was approximately 5 times more potent than l‐glutamate, while the trans isomer was 105 times less potent.
α‐NH2‐pimelic acid and β‐CH3‐glutamic acid reduced the response to l‐glutamate.
It is suggested that glutamic acid may interact with the Retzius cell glutamate receptor in an extended conformation.
DOI: 10.1111/j.1476-5381.1980.tb10864.x
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