Article date: October 1978
By: M. IMPICCIATORE in Volume 64, Issue 2, pages 219-222
Histamine has a dual action on the in situ gall bladder of the guinea‐pig: a spasmogenic and a relaxant effect mediated through Hr and H2‐receptor stimulation respectively.
The contracturant action, mimicked by 2‐(2‐aminoethyl) thiazole (a specific Hx‐receptor agonist), is blocked by mepyramine and the relaxation, mimicked by dimaprit (a specific H2‐receptor agonist), is inhibited by cimetidine.
Histamine has a dual action on the in situ gall bladder of the guinea‐pig: a spasmogenic and a relaxant effect mediated through Hr and H2‐receptor stimulation respectively.
The contracturant action, mimicked by 2‐(2‐aminoethyl) thiazole (a specific Hx‐receptor agonist), is blocked by mepyramine and the relaxation, mimicked by dimaprit (a specific H2‐receptor agonist), is inhibited by cimetidine.
DOI: 10.1111/j.1476-5381.1978.tb17292.x
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