Article date: October 1978
By: T. HOSOTANI, Y. MISU in Volume 64, Issue 2, pages 163-165
When guanethidine was applied to rabbit ventricular slices at 37°C for an initial 30 min incubation period, doses of 4 × 10−5 and 8 × 10−5m irreversibly inhibited increases in efflux of noradrenaline induced by the subsequent reduction of external sodium concentrations to 18 dim. This inhibition was prevented if the temperature was reduced to 0°C during the drug application period. Guanethidine transported into adrenergic nerve endings appears to increase permeability to Na+, thereby leading to the reduction in efflux.
DOI: 10.1111/j.1476-5381.1978.tb17285.x
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