Article date: October 1978
By: L. EDVINSSON, J.E. HARDEBO in Volume 64, Issue 2, pages 281-283
In an attempt to characterize further the nature of the 5‐hydroxytryptamine (5‐HT)‐induced contraction of intracranial vessels, cat's middle cerebral artery was exposed to this amine and the specific 5‐HT receptor antagonist, methergoline, under standardized conditions in vitro. Methergoline, in increasing concentrations, produced a parallel shift of the log dose‐response curve for 5‐HT.
The Arunlakshana‐Schild plot gave a straight line with a slope of −0.85. The figure corresponding to the pA2 value was 8.80.
The findings offer further support for the assumption that the 5‐HT‐induced intracranial vasoconstriction is mediated by specific 5‐HT receptors.
In an attempt to characterize further the nature of the 5‐hydroxytryptamine (5‐HT)‐induced contraction of intracranial vessels, cat's middle cerebral artery was exposed to this amine and the specific 5‐HT receptor antagonist, methergoline, under standardized conditions in vitro. Methergoline, in increasing concentrations, produced a parallel shift of the log dose‐response curve for 5‐HT.
The Arunlakshana‐Schild plot gave a straight line with a slope of −0.85. The figure corresponding to the pA2 value was 8.80.
The findings offer further support for the assumption that the 5‐HT‐induced intracranial vasoconstriction is mediated by specific 5‐HT receptors.
DOI: 10.1111/j.1476-5381.1978.tb17301.x
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