Article date: April 1978
By: SHAILESH P. BANERJEE, VIRENDRA K. SHARMA in Volume 62, Issue 4, pages 475-479
The specific [3H]‐ouabain binding to microsomal fractions derived from cat heart, liver, spleen, and kidney increased significantly following chronic administration of ethanol.
Since ouabain binds exclusively to cell membrane (Na+ + K+)‐adenosine triphosphatase ((Na+ + K+)‐ATPase), these results provide evidence for an increase in number of (Na+ + K +)‐ATPase macromolecules during chronic alcoholism.
The importance of the increase in number of (Na+ + K+)‐ATPase molecules in the adaptive increase in ethanol metabolism and cardiac myopathy in chronic alcoholism is discussed.
The specific [3H]‐ouabain binding to microsomal fractions derived from cat heart, liver, spleen, and kidney increased significantly following chronic administration of ethanol.
Since ouabain binds exclusively to cell membrane (Na+ + K+)‐adenosine triphosphatase ((Na+ + K+)‐ATPase), these results provide evidence for an increase in number of (Na+ + K +)‐ATPase macromolecules during chronic alcoholism.
The importance of the increase in number of (Na+ + K+)‐ATPase molecules in the adaptive increase in ethanol metabolism and cardiac myopathy in chronic alcoholism is discussed.
DOI: 10.1111/j.1476-5381.1978.tb07750.x
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