Article date: April 1978
By: DJ. BOULLIN, PATRICIA A.M. GLENTON in Volume 62, Issue 4, pages 537-542
Blood platelets from normal human volunteers were isolated and aggregated in vitro with 5‐hydroxytryptamine (5‐HT), noradrenaline (NA), dopamine and N‐dimethyldopamine (DMDA).
The effects of 5‐HT antagonists, α‐ and β‐adrenoceptor blocking agents, butyrophenones and chlorpromazine upon aggregation induced by the four amines were investigated.
Only the 5‐HT antagonists, chlorpromazine and spiroperidol were potent inhibitors of 5‐HT‐induced aggregation, and only phentolamine was a potent inhibitor of the catecholamine‐induced aggregation.
Evidence was obtained for two populations of receptors, one for 5‐HT and one for the three catecholamines.
Blood platelets from normal human volunteers were isolated and aggregated in vitro with 5‐hydroxytryptamine (5‐HT), noradrenaline (NA), dopamine and N‐dimethyldopamine (DMDA).
The effects of 5‐HT antagonists, α‐ and β‐adrenoceptor blocking agents, butyrophenones and chlorpromazine upon aggregation induced by the four amines were investigated.
Only the 5‐HT antagonists, chlorpromazine and spiroperidol were potent inhibitors of 5‐HT‐induced aggregation, and only phentolamine was a potent inhibitor of the catecholamine‐induced aggregation.
Evidence was obtained for two populations of receptors, one for 5‐HT and one for the three catecholamines.
DOI: 10.1111/j.1476-5381.1978.tb07758.x
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