Article date: September 1977
By: J. MORISSET, K.H. NG, G.G. POIRIER in Volume 61, Issue 1, pages 97-100
Secretion of amylase from rat pancreas stimulated by urecholine was studied in relation to its inhibition by atropine and 3‐quinuclidinyl benzilate (QNB).
Urecholine‐induced secretion was completely abolished by atropine at 10−6 M and QNB at 10−8 M. Significant inhibition could be detected at 10−8 M atropine and 10−10 M QNB.
The secretory response to pancreozymin was not blocked either by atropine or QNB.
The inhibitory effect of QNB remained for at least 90 min after its removal from the incubation medium.
It is concluded that QNB is 10 times more potent than atropine in inhibiting pancreatic amylase secretion induced by urecholine.
Secretion of amylase from rat pancreas stimulated by urecholine was studied in relation to its inhibition by atropine and 3‐quinuclidinyl benzilate (QNB).
Urecholine‐induced secretion was completely abolished by atropine at 10−6 M and QNB at 10−8 M. Significant inhibition could be detected at 10−8 M atropine and 10−10 M QNB.
The secretory response to pancreozymin was not blocked either by atropine or QNB.
The inhibitory effect of QNB remained for at least 90 min after its removal from the incubation medium.
It is concluded that QNB is 10 times more potent than atropine in inhibiting pancreatic amylase secretion induced by urecholine.
DOI: 10.1111/j.1476-5381.1977.tb09745.x
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