Article date: July 1977
By: F.F. BROWN, P.J. GOODFORD in Volume 60, Issue 3, pages 337-341
1 Two bis‐arylhydroxysulphonic acids were previously designed to interact with the known molecular configuration of the 2,3‐diphosphoglycerate (DPG) receptor‐site of human haemoglobin. These compounds liberate oxygen from the haemoglobin similarly to DPG.
2 Solutions of haemoglobin have now been observed under physiological conditions by nuclear magnetic resonance (n.m.r.) in the presence of DPG and of the compounds.
3 Two peaks in the n.m.r. spectrum of haemoglobin are shifted when DPG is added to the solution.
4 The same two peaks in the spectrum are affected by the compounds.
5 The observations are compatible with the predicted interaction between the compounds and the haemoglobin receptor site.
DOI: 10.1111/j.1476-5381.1977.tb07505.x
View this article