Article date: July 1977
By: NAHLA AL‐KAISI, J.R. PARRATT, H.H. SIDDIQUI, I.J. ZEITLIN in Volume 60, Issue 3, pages 471-476
1Escherichia coli endotoxin, administered intravenously in a dose of 2mg/kg to pentobarbitone‐anaesthetized, artificially ventilated cats resulted in pulmonary hypertension, systemic hypotension and an immediate (1‐2 min) 30‐40% reduction in plasma kininogen, an effect which probably indicates a release of plasma kinins.
2 Methylprednisolone (30 mg/kg), when administered 30 min before endotoxin, did not influence the endotoxin‐induced pulmonary hypertension or systemic hypotension but completely prevented the depletion of plasma kininogen.
3 In spontaneously breathing cats, methylprednisolone, administered 30 min after endotoxin, caused a rapid repletion of kininogen and prolonged survival (47% at 6 h compared to 10% in the endotoxinalone animals). Methylprednisolone did not appear to influence lactate production or the hyperventilation observed during the delayed endotoxin shock phase.
4 It is concluded that methylprednisolone does not prevent the release, by endotoxin, of a pulmonary vasoconstrictor prostaglandin, or its effects, but that perhaps by preventing kinin release it may reduce endotoxin‐induced capillary leakage.
DOI: 10.1111/j.1476-5381.1977.tb07524.x
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