Article date: July 1977
By: C.K. MUIR, N.C. SCOTT in Volume 60, Issue 3, pages 375-378
1 The mode of action of 2‐n‐propyl‐4‐p‐tolylamino‐1,2,3‐benzotriazinium iodide (TnPBI), which induced contractures of frog rectus abdominis muscle, was investigated.
2 TnPBI caused contractures of frog rectus abdominis when the muscle had been depolarized with potassium chloride.
3 Experiments with TnPBI and caffeine in calcium‐free Ringer suggested that both compounds produce contractures by releasing intracellular bound calcium.
4 It is suggested that at least two calcium stores are involved, one of which is sensitive to caffeine while both are sensitive to TnPBI.
DOI: 10.1111/j.1476-5381.1977.tb07511.x
View this article