Article date: April 1975
By: P.M. DAWES, D.C. FAULKNER in Volume 53, Issue 4, pages 517-524
In an attempt to clarify the rǒle of the sympathetic neurone in the antihypertensive action of propranolol, the effect of this drug on responses to lumbar sympathetic nerve stimulation has been studied in the perfused hind‐limb of the dog.
No consistent reduction of maximal or submaximal responses to nerve stimulation was produced by propranolol (10 to 100 μg/kg). In contrast, potentiation of nerve‐evoked responses, as well as those to injected noradrenaline, usually occurred. Dexpropranolol (50 μg/kg) had no effect.
When neuronal uptake of noradrenaline was inhibited by desmethylimipramine or cocaine, no reduction in responses to sympathetic nerve stimulation was observed with propranolol.
No evidence was found, using α‐adrenoceptor blocking drugs, that released transmitter stimulates β‐adrenoceptors in the blood vessels of the hind‐limb.
No evidence has been found for the existence of an adrenergic neurone‐blocking action of propranolol that might contribute to the antihypertensive activity in man.
In an attempt to clarify the rǒle of the sympathetic neurone in the antihypertensive action of propranolol, the effect of this drug on responses to lumbar sympathetic nerve stimulation has been studied in the perfused hind‐limb of the dog.
No consistent reduction of maximal or submaximal responses to nerve stimulation was produced by propranolol (10 to 100 μg/kg). In contrast, potentiation of nerve‐evoked responses, as well as those to injected noradrenaline, usually occurred. Dexpropranolol (50 μg/kg) had no effect.
When neuronal uptake of noradrenaline was inhibited by desmethylimipramine or cocaine, no reduction in responses to sympathetic nerve stimulation was observed with propranolol.
No evidence was found, using α‐adrenoceptor blocking drugs, that released transmitter stimulates β‐adrenoceptors in the blood vessels of the hind‐limb.
No evidence has been found for the existence of an adrenergic neurone‐blocking action of propranolol that might contribute to the antihypertensive activity in man.
DOI: 10.1111/j.1476-5381.1975.tb07389.x
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