EFFECT OF TETRAMETHYLENEDISULPHOTETRAMINE ON THE MEMBRANE CONDUCTANCE INCREASE PRODUCED BY γ‐AMINO‐BUTYRIC ACID AT THE CRAB NEUROMUSCULAR JUNCTION

Article date: April 1975

By: W.A. LARGE in Volume 53, Issue 4, pages 598-599

The effect of tetramethylenedisulphotetramine (TETS) on the increase in membrane conductance produced by γ‐aminobutyric acid (GABA) at the hermit crab neuromuscular junction was investigated. TETS produced a dose‐dependent antagonism of GABA, which was characterized by a non‐parallel shift of the log dose‐conductance curve for GABA with a reduced maximal conductance change.

DOI: 10.1111/j.1476-5381.1975.tb07401.x

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