Article date: November 1974
By: A.R. KING, I.L. MARTIN, K. ARABELLA MELVILLE in Volume 52, Issue 3, pages 419-426
Small doses of lysergic acid diethylamide (LSD) (12.5–50 μg/kg) consistently facilitated learning of a brightness discrimination reversal.
2‐Bromo‐lysergic acid diethylamide (BOL‐148), a structural analogue of LSD, with similar peripheral anti‐5‐hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 μg/kg).
LSD, but not BOL‐148, caused a small but significant increase in brain 5‐hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 μg/kg.
Small doses of lysergic acid diethylamide (LSD) (12.5–50 μg/kg) consistently facilitated learning of a brightness discrimination reversal.
2‐Bromo‐lysergic acid diethylamide (BOL‐148), a structural analogue of LSD, with similar peripheral anti‐5‐hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 μg/kg).
LSD, but not BOL‐148, caused a small but significant increase in brain 5‐hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 μg/kg.
DOI: 10.1111/j.1476-5381.1974.tb08611.x
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