Article date: May 1973
By: T. D. THOMSON, S. A. TURKANIS in Volume 48, Issue 1, pages 48-58
The influence of barbiturates on neuromuscular transmission at end‐plates of frog sartorius muscles was investigated electrophysiologically on preparations bathed in Ringer solution containing a low concentration of calcium and a high concentration of magnesium.
Effects of a convulsant barbiturate, 5‐(2‐cyclohexylideneëthyl)‐5‐ethyl barbituric acid (CHEB), were compared with those of phenobarbitone.
CHEB and phenobarbitone increased the mean quantum content of the end‐plate potentials and decreased the mean amplitude of the miniature end‐plate potentials.
Both barbiturates enhanced the duration of the nerve‐terminal action potential and had little or no effect on the effective resistance of the skeletal muscle membrane.
The influence of barbiturates on neuromuscular transmission at end‐plates of frog sartorius muscles was investigated electrophysiologically on preparations bathed in Ringer solution containing a low concentration of calcium and a high concentration of magnesium.
Effects of a convulsant barbiturate, 5‐(2‐cyclohexylideneëthyl)‐5‐ethyl barbituric acid (CHEB), were compared with those of phenobarbitone.
CHEB and phenobarbitone increased the mean quantum content of the end‐plate potentials and decreased the mean amplitude of the miniature end‐plate potentials.
Both barbiturates enhanced the duration of the nerve‐terminal action potential and had little or no effect on the effective resistance of the skeletal muscle membrane.
DOI: 10.1111/j.1476-5381.1973.tb08221.x
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