The occurrence of tolerance to a central depressant effect of nicotine

Article date: September 1972

By: CATHLEEN F. MORRISON, JANE A. STEPHENSON in Volume 46, Issue 1, pages 151-156

. Rats were injected with 0·8 mg nicotine/kg, 0·8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.

. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.

. Rats were injected with 0·8 mg nicotine/kg, 0·8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.

. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.

DOI: 10.1111/j.1476-5381.1972.tb06857.x

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