Article date: July 1972
By: CHARLES F. SIMPSON in Volume 45, Issue 3, pages 385-390
The influence of feeding 2 levels of sotalol on the incidence of β‐aminopropionitrile (BAPN)‐induced aortic ruptures of immature turkeys was determined.
Four of 22 turkeys fed 0·12% sotalol and 0·07% BAPN died of aortic ruptures, but 6 of 21 turkeys fed only BAPN died of the syndrome.
Blood pressure, heart rate, aortic tensile strength, and aortic structure as seen by light‐ and electron‐microscope were similar in turkeys fed BAPN alone or both BAPN and 0·12% sotalol concurrently.
In a second experiment, 13 of 24 turkeys fed 0·7% BAPN alone died of aortic ruptures, but only 2 of 24 turkeys fed BAPN and 0·2% sotalol concurrently died of the disease.
Aortic tensile strength was lower, heart rate was faster, alterations of aortic elastic fibres as seen by light‐ and electron‐microscope were more severe, and aortic salt soluble collagen with a higher amino acid content was increased in turkeys fed only BAPN, as compared to turkeys fed both BAPN and 0·2% sotalol.
The influence of feeding 2 levels of sotalol on the incidence of β‐aminopropionitrile (BAPN)‐induced aortic ruptures of immature turkeys was determined.
Four of 22 turkeys fed 0·12% sotalol and 0·07% BAPN died of aortic ruptures, but 6 of 21 turkeys fed only BAPN died of the syndrome.
Blood pressure, heart rate, aortic tensile strength, and aortic structure as seen by light‐ and electron‐microscope were similar in turkeys fed BAPN alone or both BAPN and 0·12% sotalol concurrently.
In a second experiment, 13 of 24 turkeys fed 0·7% BAPN alone died of aortic ruptures, but only 2 of 24 turkeys fed BAPN and 0·2% sotalol concurrently died of the disease.
Aortic tensile strength was lower, heart rate was faster, alterations of aortic elastic fibres as seen by light‐ and electron‐microscope were more severe, and aortic salt soluble collagen with a higher amino acid content was increased in turkeys fed only BAPN, as compared to turkeys fed both BAPN and 0·2% sotalol.
DOI: 10.1111/j.1476-5381.1972.tb08095.x
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