Article date: December 1971
By: D. G. GRAHAME‐SMITH in Volume 43, Issue 4, pages 856-864
The hyperactivity and hyperpyrexia produced by l‐tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine.
Chlorpromazine did not inhibit the increased rate of synthesis of brain 5‐hydroxytryptamine (5‐HT) produced by tryptophan loading.
Hyperactivity and hyperpyrexia were also produced by 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeODMT) in rats. Pretreatment with a monoamine oxidase inhibitor potentiated the hyperactivity response. Pretreatment of rats with p‐chlorophenylalanine did not inhibit hyperactivity produced by 5‐MeODMT.
Chlorpromazine inhibits hyperactivity caused by tryptophan or 5‐MeODMT after monoamine oxidase inhibition either by competition with 5‐HT or 5‐MeODMT, respectively, at receptor sites or by physiological antagonism.
The hyperactivity and hyperpyrexia produced by l‐tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine.
Chlorpromazine did not inhibit the increased rate of synthesis of brain 5‐hydroxytryptamine (5‐HT) produced by tryptophan loading.
Hyperactivity and hyperpyrexia were also produced by 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeODMT) in rats. Pretreatment with a monoamine oxidase inhibitor potentiated the hyperactivity response. Pretreatment of rats with p‐chlorophenylalanine did not inhibit hyperactivity produced by 5‐MeODMT.
Chlorpromazine inhibits hyperactivity caused by tryptophan or 5‐MeODMT after monoamine oxidase inhibition either by competition with 5‐HT or 5‐MeODMT, respectively, at receptor sites or by physiological antagonism.
DOI: 10.1111/j.1476-5381.1971.tb07222.x
View this article