Article date: December 1971
By: K. HASHIMOTO, S. SATOH, O. TAKEUCHI in Volume 43, Issue 4, pages 739-746
Effects of l‐dopa and dopamine on the secretion of pancreatic juice were investigated in preparations of the isolated blood‐perfused canine pancreas.
Dopamine (1–10 μg) given intra‐arterially caused a profuse flow of juice.
The secretory activity of dopamine (3 μg) was approximately equal to that of secretin (0·1 unit).
l‐Dopa (10–100 μg) given by a single intra‐arterial injection was ineffective, but infusion at 100 μg/min for 10 min caused a marked increase of secretion after a delay of a few minutes.
Intravenous administration of either l‐dopa (3 mg/kg) or dopamine (10–100 μg/kg) elicited a marked increase of pancreatic secretion, but was definitely less effective than intra‐arterial injection.
Dopamine‐induced secretion was not modified by atropine, phentolamine, propranolol, guanethidine or tetrodotoxin.
It is concluded that dopamine acts directly on the exocrine cells in the pancreas.
Effects of l‐dopa and dopamine on the secretion of pancreatic juice were investigated in preparations of the isolated blood‐perfused canine pancreas.
Dopamine (1–10 μg) given intra‐arterially caused a profuse flow of juice.
The secretory activity of dopamine (3 μg) was approximately equal to that of secretin (0·1 unit).
l‐Dopa (10–100 μg) given by a single intra‐arterial injection was ineffective, but infusion at 100 μg/min for 10 min caused a marked increase of secretion after a delay of a few minutes.
Intravenous administration of either l‐dopa (3 mg/kg) or dopamine (10–100 μg/kg) elicited a marked increase of pancreatic secretion, but was definitely less effective than intra‐arterial injection.
Dopamine‐induced secretion was not modified by atropine, phentolamine, propranolol, guanethidine or tetrodotoxin.
It is concluded that dopamine acts directly on the exocrine cells in the pancreas.
DOI: 10.1111/j.1476-5381.1971.tb07209.x
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