Article date: February 1970
By: G. A. BUCKLEY, C. C. JORDAN in Volume 38, Issue 2, pages 394-398
. The effects of adrenaline on the isolated frog's heart at 27° C are not antagonized by phentolamine (1·5 × 10−6m) but are abolished at 7° C.
. At 27° C isoprenaline was more potent than noradrenaline, but at 7° C noradrenaline was more potent than isoprenaline.
. Phenoxybenzamine (1·5 × 10−5m) or dibenamine (1·5 × 10−5m) at 7° C abolished the work output induced by adrenaline. When the temperature was raised to 24° C., adrenaline caused an increase in work output.
. It is concluded that in the isolated frog heart there are at least two pools of adrenoceptors, the availability of which can be governed by temperature.
. The effects of adrenaline on the isolated frog's heart at 27° C are not antagonized by phentolamine (1·5 × 10−6m) but are abolished at 7° C.
. At 27° C isoprenaline was more potent than noradrenaline, but at 7° C noradrenaline was more potent than isoprenaline.
. Phenoxybenzamine (1·5 × 10−5m) or dibenamine (1·5 × 10−5m) at 7° C abolished the work output induced by adrenaline. When the temperature was raised to 24° C., adrenaline caused an increase in work output.
. It is concluded that in the isolated frog heart there are at least two pools of adrenoceptors, the availability of which can be governed by temperature.
DOI: 10.1111/j.1476-5381.1970.tb08527.x
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