Article date: March 2011
By: Roger A. Sabbadini in Volume 162, Issue 6, pages 1225-1238
Sphingosine‐1‐phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age‐related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti‐S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.
DOI: 10.1111/j.1476-5381.2010.01118.x
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