Investigation of the physiological functions and possible pathological roles of Na+/HCO3− co‐transport in the heart has been hampered by uncertainty over the molecular identity of cardiac Na+/HCO3− co‐transporter(s) and the absence of selective pharmacological inhibitors. In their paper published in this issue, Ch'en and colleagues describe the extensive characterization of S0859 as a high‐affinity inhibitor of Na+/HCO3− co‐transport in cardiac myocytes (Ch'en et al., 2008). The availability of S0859 provides a powerful new tool to investigate the (patho)physiological significance of Na+/HCO3− co‐transport in the heart and other tissues.
British Journal of Pharmacology (2008) 153, 844–845; doi:10.1038/sj.bjp.0707670; published online 21 January 2008
DOI: 10.1038/sj.bjp.0707670
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