Article date: August 2005
By: Atif Ali, Farhan Jalees Ahmad, Krishna Kolappa Pillai, Divya Vohora in Volume 145, Issue 7, pages 880-884
This study was performed to investigate whether or not amiloride, a sodium–hydrogen exchanger (NHE) inhibitor, can protect against seizure development of pentylenetetrazole (PTZ)‐induced kindling in mice.
Kindling was induced by once every 2 days treatment with PTZ (25 mg kg−1 i.p.) for 5 weeks. Challenge experiments were carried out after 15 or 30 days of last treatment with PTZ.
Administration of amiloride (2 h before PTZ, in doses of 0.65 and 1.3 mg kg−1, p.o.) significantly prolonged the onset of kindling and reduced the incidence and severity of seizures in a dose‐dependent manner. The effect of amiloride on the incidence of PTZ‐induced seizures was evident even after 15 or 30 days of last treatment.
The results indicate a protective role for amiloride against PTZ‐induced kindling in mice. The possibility of mediation of such effects by NHE inhibition is discussed.
This study was performed to investigate whether or not amiloride, a sodium–hydrogen exchanger (NHE) inhibitor, can protect against seizure development of pentylenetetrazole (PTZ)‐induced kindling in mice.
Kindling was induced by once every 2 days treatment with PTZ (25 mg kg−1 i.p.) for 5 weeks. Challenge experiments were carried out after 15 or 30 days of last treatment with PTZ.
Administration of amiloride (2 h before PTZ, in doses of 0.65 and 1.3 mg kg−1, p.o.) significantly prolonged the onset of kindling and reduced the incidence and severity of seizures in a dose‐dependent manner. The effect of amiloride on the incidence of PTZ‐induced seizures was evident even after 15 or 30 days of last treatment.
The results indicate a protective role for amiloride against PTZ‐induced kindling in mice. The possibility of mediation of such effects by NHE inhibition is discussed.
British Journal of Pharmacology (2005) 145, 880–884. doi:10.1038/sj.bjp.0706291
DOI: 10.1038/sj.bjp.0706291
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