Article date: February 1997
By: J. H. GADDUM, Z. P. PICARELLI, in Volume 120, Issue S1, pages 134-139
There are two kinds of tryptamine receptor in the guinea‐pig ileum, namely the M receptors which can be blocked with morphine and the D receptors which can be blocked with dibenzyline. Atropine, an atropine‐like drug, cocaine, and methadone inhibit effects due to the M receptors, even after dibenzyline, but have no additional effect after morphine. Lysergic acid diethylamide, dihydroergotamine and 5‐benzyloxygramine inhibit effects due to the D receptors, even after morphine, but have no additional effect after dibenzyline. The M receptors are probably in the nervous tissue and the D receptors are probably in the muscles.
DOI: 10.1111/j.1476-5381.1997.tb06789.x
View this article