Article date: February 1997
By: S. H. FERREIRA, S. MONCADA, J. R. VANE, in Volume 120, Issue S1, pages 401-412
. Resting splenic venous outflow from anaesthetized dogs contains prostaglandin‐like material: the concentration increases after intra‐arterial injections of bradykinin into the spleen, and is abolished by treatment with indomethacin.
. Intra‐arterial injections of bradykinin into the spleen of lightly anaesthetized dogs elicit a dose‐dependent reflex increase in the blood pressure, which is reduced but not abolished by treatment with indomethacin.
. Addition of prostaglandin E1 or E2 either by injections or by infusions restores the reflex increase in the blood pressure due to bradykinin injections after indomethacin treatment.
. The sensitizing action of endogenously released prostaglandins at or near the afferent nerve endings is discussed.
. The analgesic activity of aspirin‐like drugs is explained in terms of the removal of the sensitizing activity of prostaglandins.
. Resting splenic venous outflow from anaesthetized dogs contains prostaglandin‐like material: the concentration increases after intra‐arterial injections of bradykinin into the spleen, and is abolished by treatment with indomethacin.
. Intra‐arterial injections of bradykinin into the spleen of lightly anaesthetized dogs elicit a dose‐dependent reflex increase in the blood pressure, which is reduced but not abolished by treatment with indomethacin.
. Addition of prostaglandin E1 or E2 either by injections or by infusions restores the reflex increase in the blood pressure due to bradykinin injections after indomethacin treatment.
. The sensitizing action of endogenously released prostaglandins at or near the afferent nerve endings is discussed.
. The analgesic activity of aspirin‐like drugs is explained in terms of the removal of the sensitizing activity of prostaglandins.
DOI: 10.1111/j.1476-5381.1997.tb06823.x
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