Article date: May 1994
By: J. Longmore, Z. Razzaque, D. Shaw, R.G. Hill, in Volume 112, Issue 1, pages 176-178
The effects of the NK1‐receptor antagonists, (±)‐CP 96,345 and CP 99,994, on NK1‐agonist evoked contractions were compared in isolated rings of guinea‐pig tracheal smooth muscle.
(±)‐CP 96,345 and CP 99,994 were similarly effective in antagonizing responses evoked by septide, whereas CP 99,994 was more effective than (±)‐CP 96,345 in inhibiting responses evoked by [Sar9Met11(O2)] substance P.
These results suggest that responses to septide and [Sar9Met11(O2)] substance P may be operated via different populations of NK1‐receptors.
The effects of the NK1‐receptor antagonists, (±)‐CP 96,345 and CP 99,994, on NK1‐agonist evoked contractions were compared in isolated rings of guinea‐pig tracheal smooth muscle.
(±)‐CP 96,345 and CP 99,994 were similarly effective in antagonizing responses evoked by septide, whereas CP 99,994 was more effective than (±)‐CP 96,345 in inhibiting responses evoked by [Sar9Met11(O2)] substance P.
These results suggest that responses to septide and [Sar9Met11(O2)] substance P may be operated via different populations of NK1‐receptors.
DOI: 10.1111/j.1476-5381.1994.tb13048.x
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