Article date: October 1993
By: Michel Y. Farhat, Ming‐Fong Chen, Tahira Bhatti, Azhar Iqbal, Seedabarum Cathapermal, Peter W. Ramwell, in Volume 110, Issue 2, pages 719-723
We studied the effects of oestradiol 17β on the development of pulmonary vascular changes and right ventricular (RV) hypertrophy in response to monocrotaline in male Sprague‐Dawley rats.
Rats were treated with either placebo or oestradiol 17β (10 mg) in the form of slow release pellets implanted subcutaneously 48 h before monocrotaline administration. Rats were injected with either saline or a single dose of monocrotaline (60 mg kg−1, i.m.). Pulmonary vascular changes and RV hypertrophy were studied at 4 weeks following monocrotaline administration.
Monocrotaline induced a significant increase in the ratio of right ventricle (RV) to left ventricle‐plus‐septum (LV + S) weights. Monocrotaline‐treated rats also showed significant myointimal proliferation in small pulmonary arteries, decrease of arterial numbers and increase in the number of abnormal alveolar macrophages.
Oestradiol 17β attenuated myointimal hyperplasia in pulmonary vessels, decreased the RV/(LV + S) ratio in monocrotaline‐treated rats. Oestradiol 17β had no significant effect on control animals.
Oestradiol treatment prevented the increase in lung wet to dry weight ratio, observed 7 days post monocrotaline administration.
These results suggest that oestradiol 17β protects against the pulmonary vascular remodelling and RV hypertrophy associated with monocrotaline‐induced pulmonary hypertension in the rat. Oestradiol also protects against microvascular leak observed in the early days of lesion.
We studied the effects of oestradiol 17β on the development of pulmonary vascular changes and right ventricular (RV) hypertrophy in response to monocrotaline in male Sprague‐Dawley rats.
Rats were treated with either placebo or oestradiol 17β (10 mg) in the form of slow release pellets implanted subcutaneously 48 h before monocrotaline administration. Rats were injected with either saline or a single dose of monocrotaline (60 mg kg−1, i.m.). Pulmonary vascular changes and RV hypertrophy were studied at 4 weeks following monocrotaline administration.
Monocrotaline induced a significant increase in the ratio of right ventricle (RV) to left ventricle‐plus‐septum (LV + S) weights. Monocrotaline‐treated rats also showed significant myointimal proliferation in small pulmonary arteries, decrease of arterial numbers and increase in the number of abnormal alveolar macrophages.
Oestradiol 17β attenuated myointimal hyperplasia in pulmonary vessels, decreased the RV/(LV + S) ratio in monocrotaline‐treated rats. Oestradiol 17β had no significant effect on control animals.
Oestradiol treatment prevented the increase in lung wet to dry weight ratio, observed 7 days post monocrotaline administration.
These results suggest that oestradiol 17β protects against the pulmonary vascular remodelling and RV hypertrophy associated with monocrotaline‐induced pulmonary hypertension in the rat. Oestradiol also protects against microvascular leak observed in the early days of lesion.
DOI: 10.1111/j.1476-5381.1993.tb13871.x
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