Article date: November 1991
By: Bruno Allard, Vincent Jacquemond, Fouad Lemtiri‐Chlieh, Bernard Pourrias, Oger Rougier, in Volume 104, Issue 3, pages 714-718
Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre.
Heptaminol had no action on the sodium, potassium and calcium voltage‐dependent ionic conductances.
The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension.
The action of heptaminol was suppressed in sodium‐free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed.
These results could be explained by a stimulation of the Na/H antiport by heptaminol.
Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre.
Heptaminol had no action on the sodium, potassium and calcium voltage‐dependent ionic conductances.
The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension.
The action of heptaminol was suppressed in sodium‐free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed.
These results could be explained by a stimulation of the Na/H antiport by heptaminol.
DOI: 10.1111/j.1476-5381.1991.tb12493.x
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