Article date: October 1991
By: M.R. Hirji, J.C. Mucklow, in Volume 104, Issue 2, pages 550-553
Osmotic water movement across toad isolated hemibladders was measured by a gravimetric method.
The influence of carbamazepine, chlorpropamide and demeclocycline on the antidiuretic hormone (ADH)‐induced water flow rate was examined.
No antidiuretic activity due to carbamazepine alone was observed but a slight inhibition due to ADH‐induced water flow was observed in the presence of carbamazepine over a selected dose‐range. This was unexpected and is inconsistent with data from in vivo studies in man.
Chlorpropamide potentiated ADH‐induced water flow, in keeping with the hypothesis that chlorpropamide sensitizes the renal tubules to ADH‐induced water flow.
Demeclocycline inhibited ADH‐induced water flow. The mechanism of action remains unclear.
Osmotic water movement across toad isolated hemibladders was measured by a gravimetric method.
The influence of carbamazepine, chlorpropamide and demeclocycline on the antidiuretic hormone (ADH)‐induced water flow rate was examined.
No antidiuretic activity due to carbamazepine alone was observed but a slight inhibition due to ADH‐induced water flow was observed in the presence of carbamazepine over a selected dose‐range. This was unexpected and is inconsistent with data from in vivo studies in man.
Chlorpropamide potentiated ADH‐induced water flow, in keeping with the hypothesis that chlorpropamide sensitizes the renal tubules to ADH‐induced water flow.
Demeclocycline inhibited ADH‐induced water flow. The mechanism of action remains unclear.
DOI: 10.1111/j.1476-5381.1991.tb12466.x
View this article