Article date: September 1991
By: Russell E.A. Smith, Richard M.J. Palmer, Salvador Moncada, in Volume 104, Issue 1, pages 5-6
The coronary vasoconstriction induced by the thromboxane mimetic U46619 (9, 11 dideoxy methanoepoxy 9α, 11α prostaglandin F2α, 3–30 nm) was significantly attenuated in hearts obtained from rabbits treated with endotoxin (lipopolysaccharide, LPS, 200 μg kg−1, i.v.) 4 h before isolation of the heart. Under these conditions the vasoconstriction induced by two inhibitors of nitric oxide (NO) synthase, NG‐monomethyl‐l‐arginine (l‐NMMA) and N‐iminoethyl‐l‐ornithine (l‐NIO) (1–100 μm for each) was significantly enhanced when compared to that induced in hearts from control animals. Both the decreased response to U46619 and the increased response to inhibitors of NO synthase were significantly attenuated by administration of dexamethasone (4 mg kg−1, i.v.) 90 min before treatment with LPS. These data are consistent with the induction, by LPS, of an NO synthase, and the inhibition of this induction by dexamethasone. The enhanced NO synthesis contributes to the haemodynamic changes known to occur in endotoxin shock.
DOI: 10.1111/j.1476-5381.1991.tb12375.x
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