Article date: December 1963
By: H. JACKSON, R. M. V. JAMES in Volume 21, Issue 3, pages 581-589
Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the poly‐functional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.
DOI: 10.1111/j.1476-5381.1963.tb02025.x
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