Article date: June 1963
By: MARY F. LOCKETT, C. N. ROBERTS in Volume 20, Issue 3, pages 443-448
The actions of a closed‐ring [spironolactone, SC‐9420, β‐(7α‐acetylthio‐17β‐hydroxy‐3‐oxoandrost‐4‐en‐17α‐yl)propionic acid lactone] and of an open‐ring [SC‐11480, potassium β‐(17β‐hydroxy‐3‐oxoandrosta‐1,4‐dien‐17α‐yl)propionate] spirolactone have been examined on the cat perfused kidney, in concentrations ranging from 5 to 20 mg per 150 ml. of blood. Both compounds had weak aldosterone‐like effects and caused antidiuresis with retention of sodium, potassium and chloride. The urinary changes they induced summed with those of aldosterone, without competition. Neither spironolactone nor SC‐11480 affected renal blood flow or glomerular filtration rate. Both compounds antagonized the reduction in renal vascular resistance caused by aldosterone in these preparations.
DOI: 10.1111/j.1476-5381.1963.tb01481.x
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