Article date: October 1962
By: M. J. SELLER, R. G. SPECTOR in Volume 19, Issue 2, pages 271-273
Leptazol B.P. (0.2 ml./kg) produced convulsions in 65% of normal adult rats with no fatalities. The same dose of leptazol in animals which had previously been given 0.125 mg/kg aldosterone resulted in fits in 70.2% with 7.7% deaths. Cortisol pretreatment (25 mg/kg) resulted in fits in 82.9%, and 12.2% of the animals died in convulsions. The incidence of convulsions in the animals treated with aldosterone and leptazol was not significantly increased above the animals treated with leptazol. The cortisol‐leptazol group did exhibit a significantly raised incidence of fits.
DOI: 10.1111/j.1476-5381.1962.tb01188.x
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