Article date: December 1961
By: PATRICIA M. HARRISON, G. T. STEWART in Volume 17, Issue 3, pages 420-423
The excretion of antibiotics in the bile of rats has been studied. Penicillins, including derivatives of 6‐aminopenicillanic acid, are rapidly excreted, reabsorbed and re‐excreted, in high concentration, whereas streptomycin, neomycin, paramomycin and chloramphenicol reach lower levels in the bile than in the plasma. p‐Aminobenzylpenicillin and d(—)‐6‐(α‐amino‐α‐phenylacetamido)penicillanic acid, both of which are bactericidal to Salmonellae and other conforms, produce higher concentrations in the bile than benzylpenicillin (penicillin G). This may be of therapeutic importance.
DOI: 10.1111/j.1476-5381.1961.tb01128.x
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