Article date: December 1961
By: R. A. WEBSTER in Volume 17, Issue 3, pages 507-518
The anti‐tetanus activity of a number of phenothiazine derivatives and other centrally acting muscle relaxants, such as mephenesin, dicyclopropyl ketoxime, 2‐amino‐6‐methylbenzothiazole and meprobamate, has been determined in rabbits with experimental local tetanus. Structure‐activity relationships were obtained for the phenothiazine derivatives and their anti‐tetanus activity correlated with other central and peripheral properties. Both dicyclopropyl ketoxime and 2‐amino‐6‐methyl‐benzothiazole were twice as active as mephenesin. Meprobamate does not appear to be primarily a muscle relaxant of the mephenesin type.
DOI: 10.1111/j.1476-5381.1961.tb01137.x
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