Article date: December 1961
By: E. C. HERTZLER in Volume 17, Issue 3, pages 406-413
Rat stellate ganglia were isolated and maintained in a moist chamber in which they were intermittently immersed in physiological saline containing low concentrations of the compound under investigation. 5‐Hydroxytryptamine (serotonin) in concentrations as low as 1.3 × 10−6m reduced reversibly the threshold and increased the amplitude of responses to preganglionic stimulation. Certain antagonists of 5‐hydroxytryptamine depressed reversibly the postsynaptic responses. Experiments in vivo supported this finding. It is suggested that 5‐hydroxytryptamine facilitates transmission in the sympathetic ganglia of rats.
DOI: 10.1111/j.1476-5381.1961.tb01126.x
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